Representative photomicrographs of Day 21 mouse lungs stained with hematoxylin and eosin and observed at ×20 magnification. The lungs of mice in the RA experiment are demonstrated in A. Control (panel A), animals treated with RA (panel B), animals treated with SU1498 (panel C), animals treated with SU1498 + retinoic acid (panel D). The lungs of mice in the EPO experiment are demonstrated in B. Control (panel E), animals treated with EPO (panel F), animals treated with SU1498 (panel G), animals treated with SU1498 + EPO (panel H). Larger airspaces can be appreciated in the SU1498-treated mice (panels C and G) when compared with untreated controls (panels A and E). Concomitant RA or EPO treatment maintains alveolar size similar to that of control animals (panels D and H). Bars denote 100 μm.