TABLE 2.
EFFECTS OF SU1498, RETINOIC ACID, AND ERYTHROPOIETIN ON VOLUME DENSITY OF AIRSPACE AND ALVEOLAR TISSUE IN TREATED MICE
| Groups | Airspace VD (%) | Alveolar Tissue VD (%) | Large Blood Vessel VD (%) | Conducting Airway VD (%) |
|---|---|---|---|---|
| A. RA Experiment | ||||
| Control | 40.1 ± 2.5 | 49.0 ± 3.1 | 5.4 ± 0.5 | 5.6 ± 0.8 |
| RA | 42.1 ± 1.6 | 48.9 ± 1.9 | 4.8 ± 0.8 | 5.2 ± 0.7 |
| SU1498 | 50.8 ± 1.7* | 41.0 ± 1.2* | 4.3 ± 0.9 | 4.2 ± 0.7 |
| RA + SU1498 | 49.2 ± 1.9* | 42.4 ± 2.2 | 4.2 ± 0.8 | 4.8 ± 0.6 |
| B. EPO Experiment | ||||
| Control | 44.1 ± 5.3 | 48.2 ± 4.3 | 3.8 ± 0.7 | 4.7 ± 1.2 |
| EPO | 49.9 ± 4.1 | 42.3 ± 2.6 | 2.4 ± 0.6 | 5.1 ± 0.4 |
| SU1498 | 55.2 ± 1.7* | 41.7 ± 2.9* | 2.0 ± 1.0 | 2.2 ± 0.6 |
| EPO + SU1498 | 50.1 ± 1.7 | 43.9 ± 1.7 | 3.5 ± 2.7 | 2.7 ± 0.9 |
Definition of abbreviations: EPO, eryhtropoietin; RA, retinoic acid; VD, volume density.
Morphometric analysis was performed on lung tissue to determine the VDs of airspace and tissue components. VD values expressed in the table represent mean ± SEM (n = 3–8).
*
P < 0.05 versus control.