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. 2005 Jul 13;33(4):406–411. doi: 10.1165/rcmb.2005-0140OC

Figure 4.

Figure 4.

The effect of IL-10 on HIV-LTR activity and HIV-1 replication in monocytes and macrophages. (A) IL-10 has no effect on LTR activity in undifferentiated monocytic cells, while IFN-β produces a 40% reduction of LTR activity (black bars). IFN-β or IL-10 inhibit HIV-1 LTR–driven CAT production in differentiated BF-24 cells 24 h after treatment (hatched bars). IL-10 produces a 60% inhibition, while IFN-β produces a 90% inhibition. The reporter activity in the absence of stimuli is defined as 1. (B) IL-10 has no effect on mRNA expression after infection of monocytic cells with pseudotyped HIV-1 with luciferase substituted for the envelope gene. IFN-β produces a 40% reduction in undifferentiated cells. IL-10 and IFN-β produce a 50% reduction in reporter expression in differentiated THP-1 cells. The reporter activity in the absence of stimuli is defined as 1.