Table 4.
Genotype frequencies for PTPN11 rs2301756 polymorphism, odds ratios (ORs) and 95% confidence intervals (CIs) of gastric atrophy in the H. pylori seropositive subjects (a) and H.pylori infected subjects (b)
| (a) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Genotype, allele | n | All gastric atrophy (%) | ORa | 95% CI | P valueb | Severe gastric atrophy (%) | ORb | 95% CI | P valueb |
| G/G | 643 | 350 (54.4) | 1 | Reference | - | 127 (19.8) | 1 | Reference | - |
| G/A | 266 | 131 (49.2) | 0.82 | 0.62–1.10 | 0.194 | 38 (14.3) | 0.70 | 0.47–1.04 | 0.079 |
| A/A | 28 | 14 (50.0) | 0.84 | 0.39–1.81 | 0.650 | 3 (10.7) | 0.56 | 0.17–1.91 | 0.356 |
| G/A+A/A | 294 | 145 (49.3) | 0.83 | 0.62–1.09 | 0.182 | 41 (13.9) | 0.68 | 0.46–1.01 | 0.057 |
| G | 1552 | 831 (53.5) | 1 | Reference | - | 292 (18.8) | 1 | Reference | - |
| A | 322 | 159 (49.4) | 0.85 | 0.66–1.08 | 0.097 | 44 (13.7) | 0.67 | 0.45–0.96 | 0.015 |
| (b) | |||||||||
| Genotype, allele | n | All gastric atrophy (%) | ORa | 95% CI | P valueb | Severe gastric atrophy (%) | ORa | 95% CI | P valueb |
| G/G | 677 | 383 (56.6) | 1 | Reference | - | 151 (22.3) | 1 | Reference | - |
| G/A | 274 | 139 (50.7) | 0.80 | 0.60–1.06 | 0.123 | 41 (15.0) | 0.63 | 0.43–0.93 | 0.019 |
| A/A | 28 | 14 (50.0) | 0.77 | 0.36–1.67 | 0.512 | 3 (10.7) | 0.49 | 0.14–1.67 | 0.254 |
| G/A+A/A | 302 | 153 (50.7) | 0.80 | 0.60–1.05 | 0.106 | 44 (14.6) | 0.62 | 0.42–0.90 | 0.012 |
| G | 1628 | 905 (55.6) | 1 | Reference | - | 343 (21.1) | 1 | Reference | - |
| A | 330 | 167 (50.6) | 0.82 | 0.64–1.05 | 0.102 | 47 (14.2) | 0.62 | 0.44–0.87 | 0.005 |
aOR for each genotype was calculated by age and sex adjusted logistic regression model, and a crude OR was calculated for each allele.
bP values less than 0.05 are shown in Italics.