Table 5.
Genotype frequencies for PTPN11 rs2301756 polymorphism, age-sex adjusted odds ratios (ORs) and 95% confidence intervals (CIs) of gastric cancer relative to H. pylori infected subjects without gastric atrophy (HP-infected without atrophy).
| Genotype | HP infected without atrophy n = 442 | Gastric cancer n = 583 | OR | 95% CI | P value |
|---|---|---|---|---|---|
| G/G | 293 (66.3%) | 396 (67.9%) | 1 | Reference | - |
| G/A | 135 (30.5%) | 174 (29.8%) | 0.97 | 0.74–1.28 | 0.839 |
| A/A | 14 (3.2%) | 13 (2.2%) | 0.71 | 0.33–1.53 | 0.381 |
| G/A+A/A | 149 (33.7%) | 187 (32.1%) | 0.95 | 0.73–1.23 | 0.689 |
| G | 721 (81.6%) | 966 (82.8%) | 1 | Reference | - |
| A | 163 (18.4%) | 200 (17.2%) | 0.92 | 0.72–1.16 | 0.243 |
aOR for each genotype was calculated by age and sex adjusted logistic regression model, and a crude OR was calculated for each allele.