FIG. 7.
Antitumor activity of Adeno-hTERT-E1A and ONYX-015 in an MDA-MB-231 tumor xenograft model. MDA-MB-231v tumor xenografts were implanted in the flanks of scid mice and treated with 1 × 109 PFU of each virus by intratumoral injection (arrows) as described in Materials and Methods. Shown in (A) are relative tumor volumes, normalized to the tumor volume on the first day of viral injection (day 0). (B) Mouse body weight data. Values shown represent means and SE for n = 6 mice and n = 12 tumors per treatment group. Oneway analysis of variance of tumor volume data with Bonferroni multiple test correction yielded the following significance values: p < 0.001 for PBS vehicle injected (control) versus Adeno-hTERT-E1A treated (Ad-hTERT), p < 0.01 for control versus ONYX-015 treated, and p < 0.05 for Ad-hTERT versus ONYX-015 treated. See Table 2 for tumor growth delay and volume growth inhibition analysis.