Table 2.

miRNAs differentially expressed in lung cancer tissues and normal lung tissues from 28 never-smokers

Mature miR	Probe	Location	P-value†	FDR‡	Type§	Ratio¶	Host gene‖
miR-21	hsa-mir-21-prec-17	17q23.1	3.0E-04	0.01	Up	2.35	TMEM49
miR-21	hsa-mir-21–1	17q23.1	9.6E-04	0.03	Up	2.22	TMEM49
miR-141	hsa-mir-141-prec-1	12p13.31	0.001	0.03	Up	1.50	Intergenic
miR-210	hsa-mir-210-prec	11p15.5	0.002	0.06	Up	1.51	Intergenic
miR-200b	hsa-mir-200b	1p36.33	0.008	0.11	Up	1.39	Intergenic
miR-346	hsa-mir-346	10q23.2	0.009	0.12	Up	1.14	GRID-1
miR-126*	hsa-mir-126*-1	9q34.3	3.5E-05	0.01	Down	0.45	EGFL7
miR-126	hsa-mir-126	9q34.3	0.004	0.07	Down	0.69	EGFL7
miR-30a	hsa-mir-30a-prec-1	6q13	1.4E-04	0.01	Down	0.61	C6orf155
miR-30d	hsa-mir-30d-prec-2	8q24.22	1.5E-04	0.01	Down	0.57	Intergenic
miR-486	hsa-mir-486	8p11.21	2.7E-04	0.01	Down	0.45	Intergenic
miR-129	hsa-mir-129–2	11p11.2	2.8E-04	0.01	Down	0.77	Intergenic
miR-451	hsa-mir-451–1	17q11.2	4.8E-04	0.02	Down	0.46	Intergenic
miR-521	hsa-mir-521–2	19q13.41	0.005	0.08	Down	0.84	Intergenic
miR-521	hsa-mir-521–1	19q13.41	0.005	0.08	Down	0.80	Intergenic
miR-138	hsa-mir-138–1-prec	3p21.33	0.006	0.10	Down	0.72	Intergenic
miR-30b	hsa-mir-30b-prec	8q24.22	0.006	0.10	Down	0.58	Intergenic
miR-30c	hsa-mir-30c-prec	6q13	0.007	0.11	Down	0.61	C6orf155
miR-516a	hsa-mir-516a-1	19q13.41	0.008	0.11	Down	0.89	Intergenic
miR-516a	hsa-mir-516a-2	19q13.41	0.010	0.12	Down	0.90	Intergenic
miR-520	hsa-mir-520 h	19q13.41	0.009	0.12	Down	0.84	Intergenic

^†miRNA-microarray analysis was performed using pairs of tumors and corresponding normal tissues from 28 never-smokers (P < 0.01).

^‡False-discovery rate (FDR) < 0.15.

^§Up, up-regulated in tumors compared with normal tissue; down, down-regulated in tumors compared with normal tissue.

^¶Ratio of tumor to normal tissue.

^‖http://microrna.sanger.ac.uk/sequences/.