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. 2009 Jul 6;106(29):12168–12173. doi: 10.1073/pnas.0903134106

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Fig. 1. — A fly model of FTD3. (A) Schematic representation of wild-type and the FTD3-associated mutant CHMP2B proteins. CC, coiled-coil domain. CHMP2B^Intron5 lacks the C-terminal 35 aa, and methionine-178 is changed to valine. (B) Western blot analysis. Lane 1, GMR-Gal4; lane 2, GMR-Gal4:UAS-CHMP2B^Intron5; lane 3, GMR-Gal4:UAS-CHMP2B^WT. (C–H) CHMP2B^Intron5 expression caused severe degeneration in the Drosophila eye. (C and F) GMR-Gal4 flies had normal external morphology (C) and internal retinal structure (F). (D and G) CHMP2B^Intron5 expression in the eye caused black spots (D) and degeneration of internal structures in 1-day-old flies (G). (E and H) CHMP2B^WT expression caused a mild black-spot phenotype (E) and with minor effect on the internal structure in 1-day-old flies (H).