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. 2009 Jul 6;106(29):12043–12048. doi: 10.1073/pnas.0902449106

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Fig. 1. — AML1-ETO specifically inhibits LZ-dependent blood cell differentiation. (A–D) Pan-hematopoietic expression of AML1-ETO under the control of srp-gal4 does not affect plasmatocyte development (A and B: crq) but inhibits crystal cell differentiation (E and F: PO45/CG8193). This repression is not due to a reduction in lz expression (C and D: lz) but to the competition between AML1-ETO and LZ to regulate LZ target genes (G and H: PO45/CG8193). (A–H): Lateral views of stage 11 embryos. Genotypes are indicated in the lower part of each panel. Arrows in (G and H) indicate ectopic activation of PO45 induced by LZ in the plasmatocytes and posterior endoderm.