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Fluorination plots and dose-response curves. (A) FnTrp data for the M2 receptor analyzed in terms of gas phase cation–π binding energies of fluorinated indole rings vs. the log of the ratio of the FnTrp EC50 and wild-type EC50. Dashed line, W7.40; solid line, W6.48. (B) Fluorination plot as in A for W6.48 of the D2 receptor. (C) Dose–response relations for W6.48 of the D2 receptor; EC50 values plotted in B.
