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This model shows the physiological role of ACE/AT2R and ACE/AT1R complexes on endothelial and smooth muscle cells respectively in the regulation of resistance artery tone. This model illustrates the access and the activation of AT2R and AT1R under Ang I leading to a module contraction. On the other hand, under Ang II, there is a fast access of Ang II to AT1R and less to AT2R leading to a high contraction.
