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. Author manuscript; available in PMC: 2010 Jan 30.
Published in final edited form as: Mol Cell. 2009 Jan 30;33(2):237–247. doi: 10.1016/j.molcel.2008.12.026

Figure 3.

Figure 3

Activation of AMPK by U0126 is dependent on the presence of LKB1.

(A) U0126-induced activation of AMPK is dependent on LKB1 in MEFs. Immortalized Lkb1+/+ and Lkb1-/- MEFs were serum-starved and treated with 20 μM of U0126 for 2 hr.

(B) U0126-induced activation of AMPK is dependent on LKB1 in SK-Mel-28 cells. SK-Mel-28 cells were infected with lentivirus encoding two different shRNA against LKB1 (sh2 and sh3) or control shRNA (sh1), serum-starved and treated with 20 μM of U0126 for 2 hr.