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Proportions of resistant bacteria in each thigh infected with a low (A and B) or a high (C and D) inoculum 24 (A and C) or 48 (B and D) h after different total doses of marbofloxacin. Proportions obtained after single doses (•) and after fractionated doses (□) are represented. Six thighs were tested per time, inoculum size, and dosing regimen.
