TABLE 2.
TMSW, AUC0-24/MIC, and Cmax/MIC after administration of marbofloxacin for mice sacrificed after 48 h of infection with a low or high inoculuma
| Inoculum size | Total dose (mg/kg) | Fractionated dose
|
Single dose
|
||||
|---|---|---|---|---|---|---|---|
| TMSW (%) | AUC0-24/MIC (h) | Cmax/MIC | TMSW (%) | AUC0-24/MIC (h) | Cmax/MIC | ||
| Low | 4 | 57.7 | 175 | 95 | 18.9 | 175 | 375 |
| 10 | 66.6 | 450 | 237 | 19.7 | 450 | 950 | |
| 20 | 65.4 | 900 | 475 | 19.8 | 900 | 1,900 | |
| 40 | 59.4 | 1,800 | 950 | 19.8 | 1,800 | 3,800 | |
| High | 4 | 87.4 | 387 | 75 | 42.3 | 387 | 300 |
| 10 | 63.8 | 962 | 187 | 42.5 | 962 | 750 | |
| 20 | 33.8 | 1,925 | 375 | 42.5 | 1,925 | 1,500 | |
| 40 | 10.9 | 3,850 | 750 | 42.4 | 3,850 | 3,000 | |
a
The values are given for each dosing regimen (dose administration was a single dose 2 h after the infection or fractionated doses twice a day). The indices were estimated from kinetic studies performed on mice subjected to a low or high inoculum and treated with 5 mg/kg marbofloxacin.