TABLE 2.
MIC ranges of NB-002 and comparator compounds for filamentous fungi
| Species | No. of isolates | MIC range (μg/ml)
|
||||
|---|---|---|---|---|---|---|
| NB-002 | Amphotericin B | Itraconazole | Terbinafine | Ciclopirox | ||
| Aspergillus sydowii | 1 | 1 | 1 | 0.06 | 0.25 | 2 |
| Aspergillus terreus | 3 | 0.5-1 | 2-4 | 0.25-1 | 0.03-0.25 | 0.5-1 |
| Aspergillus niger | 1 | 1 | 1 | 1 | 0.03 | 0.5 |
| Paecilomyces lilacinus | 4 | 2-8 | >16 | 1->8 | 0.25-0.5 | 8-16 |
| Fusarium oxysporum | 4 | 1-2 | 4->16 | >8 | ->2 | 1-2 |
| Fusarium solani | 5 | 0.5-2 | 8->16 | >8 | >2 | 16 |
| Fusarium senitectum | 1 | 2 | 4 | 2 | 2 | 4 |
| Acremonium spp. | 5 | 0.5-2 | 0.5->16 | >8 | 0.125-1 | 0.5-4 |
| Scopulariopsis spp. | 5 | 0.5-1 | >16 | 4->8 | 1->2 | 0.5-2 |
| Scedosporium spp. | 5 | 0.25-1 | >16 | 4->8 | >2 | 0.5-8 |
| Scytalydium spp. | 10 | 1-2 | 0.5-1 | 4->8 | 0.125-1 | 0.5-1 |
| Alternaria spp. | 3 | 0.06-0.5 | 1 | 0.25-0.5 | 1-2 | 0.25-0.5 |
| Epicoccum nigrum | 3 | 0.06-1 | 0.25-1 | 0.25-0.5 | 0.03-0.06 | 0.125-2 |
| Curvularia spp. | 3 | 0.5 | 0.125-1 | 0.125-0.25 | 0.03-1 | 0.5-1 |
| Phoma spp. | 3 | 0.5-1 | 0.5-2 | 0.06-0.5 | 0.03 | 0.5-1 |
| Chaetomium spp. | 3 | 0.25 | 0.5-4 | 0.5-1 | 1-2 | 0.25-0.5 |