TABLE 3.
Susceptibilities of C. albicans isolates that are fluconazole or itraconazole resistant and azole susceptible to NB-002 and the comparator drugs
| Susceptibility and active compound | Value (μg/ml)
|
|||||
|---|---|---|---|---|---|---|
| MIC90 | MFC90 | MIC50 | MFC50 | MIC range | MFC range | |
| Fluconazole or itraconazole resistant (n = 24) | ||||||
| NB-002 | 2 | 8 | 2 | 4 | 1-2 | 2-8 |
| Fluconazole | >64 | >64 | >64 | >64 | 0.125->64 | >64 |
| Ciclopirox | 1 | >32 | 0.25 | >32 | 0.25-2 | 8->32 |
| Terbinafine | >1 | >1 | >1 | >1 | >1 | >1 |
| Itraconazole | >16 | >16 | 2 | >16 | 0.125->16 | >16 |
| Amphotericin B | 2 | 4 | 1 | 2 | 0.125-2 | 0.25-4 |
| Azole susceptible (n = 10) | ||||||
| NB-002 | 2 | 4 | 2 | 4 | 2 | 4-8 |
| Fluconazole | 0.5 | >64 | 0.5 | >64 | 0.25-64 | >64 |
| Ciclopirox | 4 | >32 | 1 | >32 | 0.25-4 | 16->32 |
| Terbinafine | >1 | >1 | >1 | >1 | >1 | >1 |
| Itraconazole | 0.5 | >16 | 0.25 | >16 | 0.031-0.5 | >16 |
| Amphotericin B | 2 | 2 | 1 | 2 | 0.25-2 | 0.25-4 |