TABLE 1.
QRDR genetic backgrounds and quinolone MICs
S. pneumoniae strain | QRDR genetic backgrounda
|
MIC (μg/ml)
|
|||||
---|---|---|---|---|---|---|---|
parC | gyrA | CIP | LVX | GAT | MXF | GAR | |
W001 | wt | wt | 0.5 | 0.5 | 0.12 | 0.06 | 0.015 |
W002 | wt | wt | 0.25 | 0.25 | 0.12 | 0.06 | 0.015 |
S001 | Asp83Asn | wt | 2 | 1 | 0.25 | 0.12 | 0.03 |
S002 | Ser79Phe | wt | 2 | 1 | 0.12 | 0.25 | 0.06 |
S003 | wt | Ser81Phe | 0.5 | 0.5 | 0.12 | 0.06 | 0.06 |
S004 | wt | Gly85Asn | 0.5 | 1 | 0.25 | 0.12 | 0.06 |
D001 | Ser79Phe | Gly85Lys | 32 | 16 | 4 | 4 | 0.25 |
D002 | Ser79Phe | Ser81Phe | 8 | 16 | 8 | 4 | 0.5 |
wt, wild type.