TABLE 3.
QRDR genetic changes in S. pneumoniae mutants generated by GAR exposure
| S. pneumoniae strain | QRDR genetic background
|
No. of mutants with indicated QRDR mutation/no. of isolated mutants (%) (n = 231)
|
||||
|---|---|---|---|---|---|---|
| parC | gyrA | ParC79 | ParC83 | GyrA81 | GyrA85 | |
| W001 | wta | wt | 0/24 (0) | 0/24 (0) | 12/24 (50) | 3/24 (12) |
| W002 | wt | wt | 0/24 (0) | 0/24 (0) | 16/24 (67) | 0/24 (0) |
| S001 | Asp83Asn | wt | 0/31 (0) | -b | 24/31 (77) | 0/31 (0) |
| S002 | Ser79Phe | wt | - | 0/33 (0) | 16/33 (48) | 3/33 (9) |
| S003 | wt | Ser81Phe | 21/32 (65) | 0/32 (0) | - | 0/32 (0) |
| S004 | wt | Ser81Phe | 18/32 (56) | 0/32 (0) | - | 0/32 (0) |
| D001 | Ser79Phe | Gly85Lys | - | 7/31 (23) | 22/31 (70) | - |
| D002 | Ser79Phe | Ser81Phe | - | 5/24 (21) | - | 12/24 (50) |
a
wt, wild type.
b
Presented mutations with original isolates.