TABLE 1.
Population parameter values for ceftobiprole from healthy volunteers
| Parametera (unit) | Mean | Median | SD |
|---|---|---|---|
| Vc (liters) | 2.849 | 2.374 | 1.409 |
| K23 (h−1) | 6.171 | 4.744 | 4.504 |
| K32 (h−1) | 5.207 | 2.652 | 5.691 |
| K24 (h−1) | 5.512 | 6.021 | 2.276 |
| K42 (h−1) | 2.962 | 1.957 | 2.422 |
| CL (liters/h) | 5.162 | 5.380 | 0.685 |
| VELF (liters) | 39.10 | 44.79 | 13.43 |
| Khydrolysis (h−1) | 44.74 | 39.46 | 33.22 |
a
Vc, volume of the central compartment; K23, K32, K24, and K42, first-order intercompartmental transfer rate constants; CL, clearance; VELF, volume of the ELF compartment; Khydrolysis, first-order rate constant of hydrolysis of prodrug to active ceftobiprole.