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Penetration of ELF by ceftobiprole in healthy volunteers from a 9,999-subject simulation
| Parameter (unit) | Mean | Median | SD | Percentile
|
|||
|---|---|---|---|---|---|---|---|
| 10th | 25th | 75th | 90th | ||||
| AUCplasma (mg·h/liter) | 98.7 | 98.1 | 13.1 | 82.4 | 89.3 | 107.1 | 115.6 |
| AUCELF (mg·h/liter) | 25.2 | 15.0 | 35.9 | 4.20 | 7.67 | 30.1 | 55.5 |
| Penetration (%) | 25.5 | 15.3 | 36.6 | 4.32 | 7.89 | 30.4 | 55.7 |
