FIG. 7.
Relationship between PK-PD parameters (f%T>MIC, fAUC/MIC, and fCmax/MIC) and the efficacy of SMP-601 against VREF TL-3273 (A) and TL-3621 (B) in the neutropenic murine thigh infection model. Each parameter is calculated from the free (unbound) serum concentration of SMP-601. The fCmax/MIC values at each dosing regimen were set to more than three against TL-3273 and more than four against TL-3621. Each symbol represents the mean data from two mice (four thighs). The dashed lines represent the organism burden at the start of chemotherapy. R2 is the coefficient of determination.