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Relationship between PK-PD parameters (f%T>MIC, fAUC/MIC, and fCmax/MIC) and efficacy of SMP-601 against MRSA SP-12249 (A) and TL-3677 (B) in the neutropenic murine thigh infection model. Each parameter is calculated from the free (unbound) serum concentration of SMP-601. Each symbol represents the mean data from two mice (four thighs). The dashed lines represent the organism burden at the start of chemotherapy. R2 is the coefficient of determination.
