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Effect of reduced cellular levels of lipid II on the depolarization of S. aureus by telavancin. (A) Bacteria treated at 37°C in MHB (closed circles) or PBS (open circles); (B) bacteria treated at 23°C in MHB (closed triangles), followed by a temperature shift to 37°C at 15 min (open triangles) and 30 min (upside-down triangles). All samples were treated with 32 μg/ml telavancin. Values represent the means ± standard deviations from three independent experiments.
