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Antagonism of telavancin-induced depolarization by d-Ala-d-Ala ligand
| dKAA concn (mM)a | MIC (μg/ml) | % Depolarization with telavancin atb:
|
|
|---|---|---|---|
| 8 μg/ml | 32 μg/ml | ||
| 0 | 0.25 | 49 ± 3 | 94 ± 8 |
| 0.05 | 0.5 | 33 ± 14 | 68 ± 13 |
| 0.5 | 1 | 17 ± 4 | 19 ± 1 |
| 5 | 4 | 7 ± 6 | 14 ± 2 |
S. aureus cells were pretreated with dKAA prior to exposure to telavancin for 60 min.
Values represent the means ± standard deviations from at least three independent experiments.
