FIG. 2.

Lyme arthritis phenotypes in C3H, B6, B6.C3-Bbaa4, and C3.B6-Bbaa4 mice infected with B. burgdorferi. Ankle measurements were taken as described in the text and used for an assessment of arthritis severity at 4 weeks after B. burgdorferi infection. Changes in measurements between the start of infection and 4 weeks postinfection are expressed as means ± standard errors. #, significantly increased (P < 0.05; Student's t test) for female (n = 18) and male (n = 16) B6.C3-Bbaa4 mice compared to those for B6 (10 female and 10 male) mice; *, significantly decreased (P < 0.05; Student's t test) for female (n = 10) and male (n = 7) C3.B6-Baab4 mice compared to those for C3H/HeN (10 female and 9 male) mice. Results are representative of three independent experiments.