TABLE 1.
Arthritis phenotypes of B. burgdorferi-infected ISCL
| ISCLa | Relevant Chr (interval in Mbp) | Phenotypeb relative to that of background strain (C3H or B6) |
|---|---|---|
| B6.C3-Bbaa1 | 4 (9.32-94.07) | Unchanged |
| C3.B6-Bbaa1 | 4 (3.58-150.08) | Ankle swelling suppressed (males only); no change in histopathology |
| B6.C3-Bbaa2-Bbaa3 | 5 (72.29-141.16) | Ankle swelling and histopathology increased relative to those in B6 mice |
| C3.B6-Bbaa2-Bbaa3 | 5 (72.29-137.53) | Ankle swelling and histopathology decreased relative to those in C3H mice |
| B6.C3-Bbaa4 | 11 (17.18-101.75) | Ankle swelling and histopathology increased relative to those in B6 mice |
| C3.B6-Bbaa4 | 11 (25.86-103.24) | Ankle swelling and histopathology decreased relative to those in C3H mice |
| B6.C3-Bbaa6 | 12 (82.01-111.54) | Unchanged |
| C3.B6-Bbaa6 | 12 (73.39-116.11) | Ankle swelling and histopathology decreased relative to those in C3H mice |
| B6.C3-Bbaa12 | 1 (171.14-196.25) | Unchanged |
| C3.B6-Bbaa12 | 1 (116.02-196.25) | Unchanged |
a
Congenic lines are described in Materials and Methods. Boldface indicates lines exhibiting significant transfer of several arthritis traits.
b
Arthritis was assessed at 4 weeks postinfection.