TABLE 2.
Histological assessment of arthritis severity in B. burgdorferi-infected B6.C3-Bbaa4 and C3.B6-Bbaa4 ISCLa
| Mouse strain (no. of mice) | Overall lesion score | Score for:
|
Total arthritis score | ||
|---|---|---|---|---|---|
| Neutrophil infiltration | Tendon sheath thickness | Reactive-reparative response | |||
| B6 (20) | 1.05 ± 0.23 | 0.50 ± 0.22 | 0.8 ± 0.19 | 0.75 ± 0.18 | 3.25 ± 0.75 |
| B6.C3-Bbaa4 (34) | 2.07 ± 0.23 | 1.14 ± 0.20 | 1.90 ± 0.24 | 1.83 ± 0.24 | 6.83 ± 0.85 |
| C3.B6-Bbaa4 (17) | 1.93 ± 0.26 | 1.64 ± 0.29 | 1.64 ± 0.23 | 1.14 ± 0.21 | 6.14 ± 0.91 |
| C3H/HeN (19) | 3.05 ± 0.19 | 2.21 ± 0.21 | 2.79 ± 0.14 | 2.79 ± 0.21 | 10.68 ± 0.67 |
a
Histopathology was assessed as described in Materials and Methods. Values shown are means ±standard errors. Boldface indicates significant difference (P < 0.05) from the value for the background strain, as determined by a Mann-Whitney U test.