TABLE 3.
Ankle swelling and histological assessment of arthritis severity in B. burgdorferi-infected C3.B6-Bbaa6 congenic micea
| Mouse strain (no. of mice) | Change (mm) in joint measurement | Overall lesion score | Score for:
|
Total arthritis score | ||
|---|---|---|---|---|---|---|
| Neutrophil infiltration | Tendon sheath thickness | Reactive-reparative response | ||||
| B6 (20) | 0.30 ± 0.10 | 2.20 ± 0.58 | 1.20 ± 0.58 | 2.00 ± 0.32 | 2.20 ± 0.58 | 7.60 ± 1.91 |
| C3.B6-Bbaa6 (27) | 0.62 ± 0.05 | 2.19 ± 0.21 | 1.73 ± 0.24 | 2.00 ± 0.20 | 1.58 ± 0.23 | 7.35 ± 0.75 |
| C3H/HeN (20) | 1.06 ± 0.14 | 3.20 ± 0.20 | 2.40 ± 0.20 | 3.00 ± 0.0 | 3.60 ± 0.24 | 11.80 ± 0.20 |
a
Histopathology was assessed as described in Materials and Methods. Values shown are means ± standard errors. Boldface indicates significant difference (P < 0.05) from the value for the C3H/HeN parent strain, as determined by a Mann-Whitney U test.