TABLE 1.
Quantitative values for parameters of infection in rhesus macaques infected by spore aerosol exposure to B. anthracis Ames strain: PA, LF, PGAa
| Factor analyzed | Animal ID | Concn (ng/ml) at indicated time point
|
|||||
|---|---|---|---|---|---|---|---|
| −42 days | 24 h | 48 h | 72 h | 96 h | 120 h | ||
| PA | A | − | − | − | − | 147* | |
| B | − | − | − | − | − | 3,153* | |
| C | − | − | − | − | −* | ||
| D | − | − | − | − | − | − | |
| E | − | − | − | − | 19,434* | ||
| LF | A | − | 0.006 | 45.16 | 10.29 | 103.08* | |
| B | − | − | 25.87 | 18.97 | 63.58 | 1,235.76* | |
| C | − | 0.200 | 51.66 | 10.57 | 34.07* | ||
| D | − | 0.018 | 38.10 | 8.06 | 4.48 | 27.73 | |
| E | − | − | 42.00 | 25.08 | 3,885.89* | ||
| GM | 0.028 | 39.53 | 13.31 | 82.78 | 185.12 | ||
| SE | 1.82 | 0.12 | 0.24 | 2.01 | 5.68 | ||
| PGA | A | − | − | 10,394 | 20 | 32,000* | |
| B | − | − | 48 | 17 | 681 | 1,126,388* | |
| C | − | − | 7,061 | 16 | 3,541* | ||
| D | − | − | 1,523 | 7 | 3 | 32 | |
| E | − | − | 6,527 | 18 | 1,965,663* | ||
| GM | 2,037 | 14 | 3,401 | 6004 | |||
| SE | 2 | 0.2 | 8 | 187 | |||
Values for PA, LF, and PGA are shown in nanograms per milliliter for 24, 48, 72, 96, and 120 h. The LF assay reported values of ≥1 ng/ml to the nearest 0.01 ng/ml and <1 ng/ml to the nearest 0.001 ng/ml. Both the PA and PGA assay measurements were reported to the nearest nanograms per milliliter. Asterisks indicate the measurement at euthanasia. Geometric means (GM) and SE were calculated by standard methods. Measurements for postexposure time points at 2, 4, 6, and 12 h were negative for all parameters and thus were not included. Due to standard requirements for blood collection during animal studies, samples for animal D from days 6 through 9 were not available for LF, PA, and PGA testing. −, negative values obtained for PA, LF, and PGA.