FIG. 4.

MAP-immune antisera contain highly avid antibody. Shown are the avidity maturation data from the second cohort of MAP-immune rabbits (MR4 to MR6) and individual avidity data from the MAP-immune rabbit (MR3) and the two positive-control PA-immune rabbits (PR1 and PR2) as determined through use of a chaotrope ELISA as described in Materials and Methods. The avidity index was determined from sera obtained 10 days after the indicated immunizations for the second group of MAP peptide-immune rabbits or after the fifth immunization for rabbits MR3, PR1, and PR2.