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. 2009 Jun 10;83(16):8108–8121. doi: 10.1128/JVI.00211-09

FIG. 5.

FIG. 5.

(A to D) NDV-infected tumor cells show enhanced susceptibility to NK cell lysis. HeLa, PANC-1, Ma-Mel-8a, and Ma-Mel-8b tumor cell lines were infected with NDV Ulster (100 HU/106 cells; 20 h) or left uninfected and were then subjected to a 4-h chromium release assay using primary, IL-2-activated NK cells from one to three different donors as effectors. The mean percentages of specific lysis ± SEM for triplicate samples at different effector/target cell ratios are indicated. (E) T98G cells were infected with NDV Ulster (100 HU/106 cells; 20 h) or MTH-68 (25 HU/106 cells; 12 h) or left uninfected and were then subjected to a 4-h chromium release assay using primary IL-2-activated NK cells. The anti-F protein MAb Icii was present during infection with MTH-68 to prevent syncytium formation. (F) Results from cytofluorometric staining of uninfected HeLa cells and NDV Ulster- and NDV MTH-68-infected HeLa cells with the pan-HLA-A-, HLA-B-, HLA-C-reactive antibody W6/32.