TABLE 1.
Distribution of latently infected neurons in murine TG following ocular inoculation with different strains of HSV-1 and HSV-2
| Strain (type) | % of LAT-positive neurons colabeled as indicated (no. of dual-labeled neurons/no. of LAT-positive neurons tested)a
|
|
|---|---|---|
| A5-positive | KH10-positive | |
| KOS (HSV-1) | 41.1 (184/448) | 2.7 (9/334) |
| 17 syn+ (HSV-1) | 39.0 (133/341) | 3.1 (11/353) |
| F (HSV-1) | 37.5 (281/748) | 7.7 (14/205) |
| McKrae (HSV-1) | 38.9 (106/272) | 2.8 (7/249) |
| AD1 (HSV-1 clinical isolate) | 48.1 (113/235) | 3.2 (9/278) |
| ST1 (HSV-1 clinical isolate) | 43.7 (184/421) | 2.3 (7/303) |
| MS (HSV-2) | 4.4 (18/409) | 52.1 (182/349) |
| HG52 (HSV-2) | 2.8 (8/289) | 43.5 (90/207) |
| 333 (HSV-2)b | 3.8 (18/468) | 40.8 (161/394) |
| S (HSV-2 clinical isolate) | 6.0 (14/231) | 52.4 (108/206) |
| Overall ganglionic compositionc | 11.5 (241/2,090) | 13.6 (301/2,209) |
a
Twenty-one days after ocular inoculation, sections of latently infected TG were assayed by combined FISH and IF.
b
Previously published data (38) presented for the purposes of comparison only.
c
For reference, the overall distribution of A5- and KH10-positive neurons (LAT-positive and LAT-negative) in ganglia latently infected with HSV-1 KOS is given.