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Dynamics of CD4+ T-cell subsets in periphery and intestine during SIVrcm infection. Significant depletion with partial restoration of naïve CD4+ T cells (CD28+ CD95−) (a and b) was observed in periphery and intestine. Memory CD4+ T cells (CD28− CD95+) showed massive depletion (c to f), with the least restoration being observed for the effector memory CD4+ T-cell population in periphery as well as intestine of SIVrcm-infected PTMs (e and f). Animal EC01, •; BU62, ▾; EC23, ▪; EC25, ♦.
