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RecQL1 depletion compromises EBV lytic replication. (A) Western blotting of EBV-positive MutuI cells infected with lentivirus containing shRNA for control (shControl) or RecQL1-targeting sequences, as indicated. (B) MutuI cells infected with shRNA-containing lentivirus as shown above (A) were induced by TPA and NaB for lytic cycle replication. Viral DNA replication was measured by real-time PCR analysis of EBV DNA relative to cellular actin.
