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Capsid diameter as determined in TX-100-extracted cell-associated virus (top), TX-100-extracted extracellular virus (middle), and C capsids isolated from the nuclei of HSV-1-infected cells (bottom). Measurements were made from electron micrographs of specimens after negative staining as described in Materials and Methods. Note the larger diameter of tegument-containing capsids (middle) compared to those lacking tegument (top and bottom).
