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Effect of SM on activity of BHRF1 promoter unlinked to oriLyt. (A) 293 cells (EBV negative) were transfected with BHRF1p-luciferase reporter plasmid and either empty vector (C) or Z or Z+SM expression plasmid. Lysates were prepared 48 h after transfection and assayed for luciferase activity. n-fold activation is shown on the y axis. (B) BMLF1KO 293 (EBV-positive) cells were transfected and assayed for luciferase expression as in panel A above.
