. Author manuscript; available in PMC: 2009 Jul 26.

Published in final edited form as: Nat Rev Drug Discov. 2008 May;7(5):426–437. doi: 10.1038/nrd2462

Table 3.

Effects of lithium or VPA on the glutamatergic system

Drug	Effect	Reference
Lithium	Alters VGLUT1 expression and presynapatic Glu release	83, 163, 165
Lithium	Alters Glu uptake	166
Lithium	Alters Glu receptor expression and function	84, 85, 153, 167, 168
VPA	Alters VGLUT1 expression and presynapatic Glu release	169, 170
VPA	Increases EAAT expression	171, 172
VPA	Alters Glu receptor expression and function	89, 153, 173–178

Abbreviations: EAAT: excitatory amino acid transporter; VGLUT: vesicular glutamate transporter; mRNA: mitochondrial RNA; VPA: valproate.