Table 3. Results from unadjusted and adjusted analyses of factors associated with mortality due to non-AIDS-defining malignancies.

	Unadjusted			Adjusted^a
	Rate ratio	95% CI	P value	Rate ratio	95% CI	P value
Latest CD4 cell count (per log₂ higher)	0.64	0.60-0.68	0.0001	0.61	0.57-0.66	0.0001
Sex/risk group
Male homosexual	1			1
Male heterosexual	0.80	0.50-1.28		0.72	0.44-1.19
Female heterosexual	0.42	0.24-0.74		0.86	0.48-1.55
Male IDU	0.88	0.58-1.35		1.38	0.87-2.21
Female IDU	0.71	0.37-1.37		1.58	0.80-3.12
Men/women/other/not known	0.77	0.45-1.33	0.04	0.57	0.32-1.01	0.07
Age (per 5 years older)	1.48	1.39-1.57	0.0001	1.60	1.49-1.72	0.0001
Previous AIDS^b	2.42	1.81-3.23	0.0001	1.30	0.95-1.78	0.10
Smoking status
Current smoker	1.81	1.21-2.70		2.89	1.86-4.48
Ex-smoker	1.88	1.17-3.04		2.01	1.22-3.32
Never smoked	1			1
Not known	1.39	0.86-2.26	0.01	1.16	0.61-2.22	0.0001
Exposure to cART
None	0.23	0.09-0.57		0.38	0.15-0.95
<4 years	1			1
≥4 years	1.62	1.20-2.18	0.0001	1.76	1.25-2.47	0.0001
Hepatitis B status
Negative	1			1
Positive - active	2.51	1.60-3.92		1.81	1.14-2.88
Positive - inactive	1.17	0.80-1.72		0.93	0.59-1.47
Vaccinated	0.43	0.11-1.74		0.46	0.11-1.92
Not known	1.31	0.89-1.91	0.002	0.60	0.36-1.00	0.004
Calendar year
1999-2001	1			1
2002	0.90	0.62-1.31		0.71	0.49-1.05
2003	0.93	0.64-1.34		0.61	0.41-0.90
2004/2005	0.52	0.33-0.82	0.02	0.30	0.19-0.48	0.0001

ADM, AIDS-defining malignancy; cART, combination antiretroviral therapy; CI, confidence interval; IDU, injecting drug user.

Adjusted for all the variables listed in the table and for cohort.

Excluding AIDS malignancies.