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. Author manuscript; available in PMC: 2009 Jul 27.
Published in final edited form as: Nat Med. 2008 Dec 21;15(1):84–90. doi: 10.1038/nm.1897

Figure 6. Decreased Seizure Susceptibility to PTZ-induced seizures.

Figure 6

Quantification of doses of PTZ (a), latency to induce generalized tonic-clonic seizures (b) and interval between minimal and generalized seizures (c) in 3 groups of animals: Malformation free animals (ineffective shRNAs and induced eGFP expression induced at P0), double cortex animals with SBH and lamination deficits (effective shRNAs and eGFP expression induced at P0) and P0 rescue animals with restored lamination and regressed SBH (effective shRNAs and DCX-eGFP expression induced at P0). (d) Example of a double cortex animal experiencing rearings, fallings and convulsions (top panels) and a P0 rescue animal at the same dose of PTZ and same time after injection (bottom panels). The P0 rescue animal experienced seizures 10 minutes later, after an additional injection of PTZ was given. *** P < 0.001, ** P < 0.01, * P < 0.05.