Table 3. A manual selection of compounds with predicted drug target(s) based on similarity in expression profiles to another drug with known target.

Drug	Predicted Target(s)	Predicted targeting pathways
Ajmaline	KCNMA1 HRH2	GPCRs in the regulation of smooth muscle tone; G-Protein Coupled Receptor Signaling; cAMP-mediated Signaling
Cicloheximide	ATP1A1	Leptin signaling via PI3K-dependent pathway
Lobeline	KCNMA1	GPCRs in the regulation of smooth muscle tone
Quercetin	NR3C2 FKBP1A	Glucocorticoid Receptor Signaling; IL-4 Signaling; Neutrophil and Its Surface Molecules; mTOR Signaling Pathway
Salbutamol	DRD2	Regulation of cell cycle progression by Plk3; Dopamine Receptor Signaling; G-Protein Coupled Receptor Signaling; cAMP-mediated Signaling
Strophanthidin	ATP1A1	Leptin signaling via PI3K-dependent pathway
Daunorubicin	TOP2A	Apoptotic DNA fragmentation and tissue homeostasis; Cell Cycle: G2/M DNA Damage Checkpoint Regulation

The last column is the list of pathways that the target of the known drug participates. Thus, the hypothesis is that the shown drug may act either through the predicted target or at least through the shown pathway.