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. 2008 Dec 18;41(2):136–145. doi: 10.1165/rcmb.2008-0363OC

Figure 4.

Figure 4.

Lower levels of expression of pulmonary XCL1 are associated with decreased numbers of CD4 and CD8 T cells. (A) Numbers of total CD4 and IFN-γ expressing CD4 T cells were reduced in mice receiving XCL1-targeting siRNA (open bars) either at 3 or 5 days after treatment when compared with control mice (closed and gray bars). (B) The same mice showed a reduction of 18–50% in IFN-γ CD4 T cells, total number of CD8 T cells, and CD8 expressing IFN-γ T cells. Mice receiving XCL1-targeting siRNA (open bars) had a 20–40% and a 28–42% reduction in CD8 T cells and CD8 T cells expressing IFN-γ, respectively, when compared with control mice (closed and gray bars). Data are representative of three independent experiments and represent the average (±SEM) of CD4 and CD8, and CD4 and CD8 expressing IFN-γ from PBS (closed bars), nontargeting siRNA (gray bars), or XCL1-targeting siRNA (open bars).