Table 1.
Bacterial growth in the organs of mice infected with various concentrations of different strains of type A F. tularensis by ID and aerosol routes.
| Expt. No. |
Mouse strain |
Francisell a strain |
Route/dose | TTD in days |
organ | Log 10 CFU± SD on day of infection proportion infe n=3-4 |
|||
|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | ||||||
| 1 | BALB/c | FSC033 | ID /103 CFU | 3-4 | skin | 6.03 ± 0.15 | 7.74 ±0.30 | 7.51± 0.80 | 8.30 ±0.10 |
| liver | 3.87 (1/3) | 5.0 ±0.14 | 7.49 ±0.85 | >10.0 (3/3) | |||||
| spleen | 2.89 (2/3) | 5.24 ±0.14 | 8.02 ±1.23 | 9.70 ±0.22 | |||||
| lung | 1.60 (1/3) | 2.45 (2/3) | 5.63 ±1.30 | 8.86 ±0.12 | |||||
| 2 | C57BL/6 | FSC033 | ID /103 CFU | 3-4 | skin | 5.66 ± 0.45 | 7.15 ±0.18 | 6.80 ±0.18 | 7.60 ±0.18 |
| liver | <2.30 (0/3) | 6.24 ±0.99 | 7.93 ±0.25 | >10.0 (3/3) | |||||
| spleen | 1.45 (2/3) | 6.77 ±1.20 | 8.68± 0.06 | 9.42 ±0.16 | |||||
| lung | <1.3 (0/3) | 4.08 ± 0.70 | 6.04 ±0.39 | 8.59 ±0.17 | |||||
| 3 | BALB/c | SCHU S4 (FSC237) |
aerosol / 10 CFU | 5-6 | skin | ND | ND | ND | ND |
| liver | <1.6 (0/4) | 3.65 ± 1.43 | 5.65 ± 0.30 | 7.71 ± 0.18 | |||||
| spleen | <1.6 (0/4) | 3.67 ± 1.24 | 6.14 ± 0.40 | 8.74 ± 0.32 | |||||
| lung | 4.03 ± 0.19 | 5.73 ± 0.21 | 6.77 ± 0.15 | 7.39 ± 0.32 | |||||
| 4 | BALB/c | SCHU S4 (FSC 237) |
aerosol / 103 CFU | 4 | skin | ND | ND | ND | ND |
| liver | <1.6 (0/4) | 5.58±0.41 | 7.32±0.35 | 8.93±0.09 | |||||
| spleen | <1.6 (0/4) | 4.76±0.63 | 7.74±1.20 | 8.83±0.72 | |||||
| lung | 4.76±0.32 | 6.99±0.25 | 7.96±0.15 | 8.39±0.04 | |||||
TTD, time to death. ND, not done