Table 1. Summary of changes of AP-1 and NF-κB activities and sensitivity to TRAIL and TNFα.
PC3 | PC3-TR | LNCaP | ||||
---|---|---|---|---|---|---|
TRAIL | TNFα | TRAIL | TNFα | TRAIL | TNFα | |
NF-κB | ↓ | ↑ | ↑ | ↑ | ↑ | NC* |
AP-1 | ↑ | NC | NC | NC | NC | ↑ |
Sensitivity | S | R | R | R | R | S |
↑: Increased activity; ↓: decreased activity ; NC: no change; S: sensitive; R: resistant
Basal level is very low.