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. Author manuscript; available in PMC: 2009 Oct 1.
Published in final edited form as: Cancer Chemother Pharmacol. 2008 Feb 2;62(5):881–891. doi: 10.1007/s00280-008-0678-x

Table 4.

Gastrointestinal toxicoses in dogs after i.v. administration of calcitriol combined with cisplatin

Calcitriol
dosage (μg/kg)		 No. of
dogs		 Vomitinga
 Anorexiaa
 Diarrheaa
1 2 3 4 5 1 2 3 4 5 1 2 3 4 5
0.1 3 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
0.25 2 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0
0.50 6 0 2 0 0 0 0 2 0 0 0 2 1 0 0 0
1.0 3 1 0 0 0 0 0 0 0 0 0 0 0 0 0 0
1.50 3 1 1 0 0 0 1 0 0 0 0 1 1 0 0 0
2.25 4 1 0 0 0 0 0 0 0 0 0 1 0 0 0 0
3.75 7 0 1 0 1 0 0 0 0 0 0 1 0 0 0 0
5.50 4 1 0 1 1 0 0 1 1 0 0 0 1 0 0 0
a

Grading criteria [1]: grade 1 (<3 episodes vomiting in 24 h; coaxing or dietary change required to maintain appetite; increase of >2 stools per day over baseline) grade 2 (3–5 episodes vomiting in 24 h or <3 episodes per day for>2 but <5 days; oral intake altered for <3 days; increase of 2–6 stools per day, parenteral fluids indicated for <24 h), grade 3 (>5 episodes vomiting in 24 h or vomiting >4 days, fluid therapy indicated; anorexia 3–5 days with weight loss; increase of >6 stools per day, incontinence, hospitalization for IV fluids), grade 4 (life-threatening vomiting or diarrhea leading to hemodynamic collapse; anorexia >5 days), grade 5 (death)