Table 5.

Pharmacokinetic variables for calcitriol in dogs after i.v. administration of a single dose

Calcitriol dosage (μg/kg)	N	Cmax (ng/mL)	t1/2 (h)	AUC0->24 h (h ng/mL)	Vz (L/kg)	Cltb (L/h/kg)
0.1	3	0.60 ± 0.02	24.1 ± 4.4	5.86 ± 0.46	0.29 ± 0.01	0.33 ± 0.00
0.25	2	1.13 ± 0.05	15.3 ± 0.2	13.1 ± 2.50	0.29 ± 0.06	0.56 ± 0.02
0.50	4	2.42 ± 0.47	7.1 ± 2.0	11.2 ± 1.20	0.38 ± 0.06	1.28 ± 0.29
1.0	1	5.20	8.1	33.2	0.24	1.01
1.50	3	7.26 ± 1.81	7.2 ± 1.6	45.1 ± 6.51	0.33 ± 0.09	0.99 ± 0.04
2.25	3	9.8 ± 1.1	4.1 ± 0.92	70.8 ± 0.91	0.16 ± 0.06	0.72 ± 0.19
3.75	4	29.0 ± 3.81	7.7 ± 1.3	119.3 ± 16.9	0.33 ± 0.06	1.01 ± 0.18
5.50	4	27.5 ± 5.43	7.1 ± 0.7	185.2 ± 8.43	0.28 ± 0.03	0.91 ± 0.07

Results represent the mean ± SEM