Table 1.
Candidate genes analyzed
| Gene symbol | Gene name | Chromosomal location | Size of gene bp | Number of polymorphic SNPs genotyped | Average interval between SNPs, kb | Number of nsSNPs |
|---|---|---|---|---|---|---|
| AGRP | agouti related peptide | 16q22 | 1,242 | 3 (2) | 110 bp | 1 |
| ADIPOQ | adiponectin, C1Q and collagen domain containing | 3q27 | 15,789 | 18 (17) | 14.0 | 1 |
| BBS1 | Bardet-Biedl syndrome 1 | 11q13 | 22,965 | 10 (9) | 5.3 | 0 |
| BBS2 | Bardet-Biedl syndrome 2 | 16q21 | 33,895 | 9 (8) | 5.1 | 0 |
| ARL6 | BBS3, ADP-ribosylation factor-like 6 | 3q11.2 | 33,778 | 7 (7) | 26.4 | 0 |
| BBS4 | Bardet-Biedl syndrome 4 | 15q22.3-q23 | 52,281 | 8 (7) | 12.0 | 0 |
| BBS5 | Bardet-Biedl syndrome 5 | 2q31 | 27,172 | 6 (6) | 76.0 | 0 |
| MKKS | BBS6, McKusick-Kaufman syndrome | 20p12 | 29,029 | 6 (5) | 2.6 | 0 |
| BBS7 | Bardet-Biedl syndrome 7 | 4q27 | 46,005 | 6 (4) | 14.0 | 0 |
| TTC8 | BBS8, tetratricopeptide repeat domain 8 | 14q31.3 | 53,354 | 4 (4) | 8.4 | 0 |
| CARTPT | cocaine- and amphetamine-regulated transcript | 5q13.2 | 1,878 | 6 (6) | 11.1 | 0 |
| CNR1 | cannabinoid receptor 1 | 6q14-q15 | 5,469 | 10 (10) | 3.0 | 0 |
| CPE | carboxypeptidase E | 4q32.3 | 119,388 | 24 (23) | 5.3 | 0 |
| GHRL | ghrelin/obestatin preprohormone | 3p26-p25 | 5,111 | 11 (8) | 1.1 | 1 |
| GHSR | ghrelin receptor, growth hormone secretagogue receptor | 3q26.31 | 3,252 | 10 (9) | 2.6 | 0 |
| GCG | glucagon | |||||
| glucagon-like peptide 1 (glucagon/GLP1/GLP2/GRPP) | 2q24.2 | 9,369 | 6 (6) | 4.0 | 1 | |
| GLP1R | glucagon-like peptide 1 receptor | 6p21 | 38,903 | 24 (22) | 2.6 | 2 |
| HTR2A | 5-hydroxytryptamine (serotonin) receptor 2A | 13q14-q21 | 62,662 | 31 (31) | 2.7 | 2 |
| HTR2C | 5-hydroxytryptamine (serotonin) receptor 2C | Xq23 | 326,073 | 20 (19) | 18.0 | 1 |
| JAK2 | Janus kinase 2 (a protein tyrosine kinase) | 9p24 | 142,750 | 18 (17) | 8.8 | 1 |
| LEP | leptin | 7q32 | 5,637 | 23 (21) | 3.7 | 0 |
| LEPR | leptin receptor | 1p31 | 212,190 | 35 (34) | 15.6 | 3 |
| MC4R | melanocortin 4 receptor | 18q22 | 998 | 10 (10) | 19.7 | 1 |
| NPY1R | neuropeptide Y receptor Y1 | 4q31.3-q32 | 8,631 | 4 (4) | 1.5 | 1 |
| NPY5R | neuropeptide Y receptor Y5 | 4q31-q32 | 7,995 | 7 (7) | 3.9 | 1 |
| PLIN | perilipin | 15q26 | 14,987 | 11 (8) | 12.8 | 3 |
| POMC | proopiomelanocortin | 2p23 | 7,664 | 13 (9) | 10.2 | 0 |
| SOCS3 | suppressor of cytokine signaling 3 | 17q25.3 | 3,294 | 6 (6) | 2.2 | 1 |
| STAT3 | signal transducer and activator of transcription 3 | 17q21 | 75,170 | 19 (18) | 4.9 | 0 |
| TUB | tubby homolog | 11p15.4 | 67,472 | 19 (18) | 4.7 | 0 |
For number of polymorphic SNPs genotyped, the number in parentheses indicates number of SNPs that were determined to be polymorphic in this study. nsSNPs are non-synonymous SNPs.