Fig 3.
One possible pathway in which pressure regulates cellular adhesion. The cytoskeleton plays a key role in transducing many of the relevant signals, but Src is activated independently of the cytoskeleton. Akt1 seems to aid in keeping FAK phosphorylated at the focal adhesion, though its role is complex and not completely understood. FAK, focal adhesion kinase; ILK, integrin-linked kinase.