Skip to main content
. Author manuscript; available in PMC: 2009 Jul 27.
Published in final edited form as: Virology. 2008 Mar 26;375(2):611–623. doi: 10.1016/j.virol.2008.02.025

Fig. 8. A working model for regulation of the hTERT promoter by E6 and E7.

Fig. 8

Results from the current and previous studies are summarized to illustrate the possible mechanism for regulation of the hTERT promoter by the HPV E6 and E7 oncoproteins. A critical regulator of hTERT transcription is the binding of Myc/Max to the promoter E box, as well as the physical interaction of E6/E6AP with this E box site. In addition, the interaction of E7 with the pRb/E2F site is also involved in regulating promoter activity. The transcription start site for hTERT mRNA is indicated.