Table 2.
Clinical trails using DCs pulsed with idiotype of Myeloma patients
| Vaccines | Patients | Clinical Outcome | Authors (Ref#) |
|---|---|---|---|
| 7 Vaccines (Id + KLH +DCs) (2-iv Id + DCs & 5- Id + KLH) |
12 AutoSCT High Dose Chemotherapy |
Stable | Reichardt et al. (71,72) |
| 3 Vaccines (Id +DCs) | 6 | Progressed | Lim et al. (67) |
| 7 Vaccines (2-Id + DCs & 5-Id+ KLH) | 26, High dose chemotherapy, AutoSCT | 17 Live/ Stable | Liso et al. (69) |
| 4 Vaccines (1-Id + DCs & 3-Id+GMCSF) | 11 | Progressed | Titzer et al. (68) |
| 3 Vaccines (Id +DCs + IL-2) | 5 High dose Chemotherapy at Stable PR | 4 Stable/1 Relapsed | Yi et al. (70) |
| 4-7 Vaccines (Id + KLH + GMCSF) |
4 AlloSCT | 3 Progressed | Bendandi et al. (73) |
Abbreviations: Id, Idiotype; KLH, keyhole limpet haemocyanin; DCs, Dendritic cells; AutoSCT, Autologous Stem Cell Transplantation; GMCSF, Granulocyte-Macrophage Colony Stimulating Factor; PR, Partial response, & IL2, Interleukin 2