Table 2.

Relative risk of MGUS and lymphoproliferative malignancies among first-degree relatives of MGUS patients

	First-degree relatives of MGUS patients (n = 14621)	First-degree relatives of controls (n = 58387)	RR (95% CI)*
MGUS	22	31	2.8 (1.4-5.6)†
Multiple myeloma	41	57	2.9 (1.9-4.3)†
Lymphoplasmacytic lymphoma/Waldenström macroglobulinemia	8	8	4.0 (1.5-11)†
Chronic lymphocytic leukemia	23	46	2.0 (1.2-2.3)†
Non-Hodgkin lymphoma	44	161	1.1 (0.8-1.5)
Hodgkin lymphoma (< 45 y)	8	24	1.3 (0.6-2.9)
Hodgkin lymphoma (> 45 y)	1	18	0.2 (0.0-1.7)

^*All estimates were adjusted for sex of first-degree relative.

^†Statistically significant (2-sided P value < .05).